Nana Nishigaki (西垣 奈々 Nishigaki Nana?) is a science teacher at Nanamori Middle School who is constantly trying various experiments, often using Rise as a test subject which always result in explosions. She is one of the few people who can understand Rise's quiet voice. She also cuts Rise's hair.

In Season 2 Episode 4, Nana displayed her prankster powers when she made up a story about how she became interested in science, involving a toy robotic puppy who stopped working. It is later revealed that when she was a school student, she accidentally plugged a miniature light bulb into a main wall socket, causing it to explode.